In-vitro toxicology

Our range of services

In-vitro toxicology

Palmur Bio has been helping clients globally to develop custom testing strategies and conduct appropriate assays to meet the unique requirements of their chemicals and drugs. With three sites in South India, and collaboration with Isoquimen in Spain, our team includes ~50 scientists and staff who are dedicated to the field of genetic toxicology, as well as regulatory consultants and program managers who can support our clients’ studies with strategic advice.

Determination of a compound’s potential genotoxicity is an important component of a complete safety assessment of nearly all new products (e.g., pharmaceutical ingredients, pharmaceutical impurities, unique human metabolites, industrial chemicals, agrochemicals, cosmetics). Performed early on, it can help to determine whether further development is appropriate and what, if any, additional testing is needed to investigate and characterize the relevance of any observed adverse effects.

Our team works closely with other Safety Assessment groups to enrich study results and integrity with supplementary services such as formulation and analytical chemistry, pathology and bioanalysis. Additionally, we can support and enhance other studies by evaluating genetic toxicology biomarkers and determining mechanism of action identification using in situ hybridization, flow cytometry and determining apoptosis if needed.

Quick overview of in-vitro services we can provide:

In-vitro Toxicity Studies

Our current in-vitro services include the following:

  • Bacterial Reverse Mutation Test (Ames test) – Full
  • Bacterial Reverse Mutation Test (Ames test) – Mini
  • In Vitro Chromosomal Aberration Test using Human Lymphocytes / CHO
  • In Vivo Chromosomal Aberration Test in rat
  • In Vivo Micronucleus Test in mice
  • In Vitro Micronucleus Test
  • Mouse Lymphoma Assay
  • Cytotoxicity Test using Balbc cell line

Analytical Chemistry Studies

We currently undertake the following Analytical Chemistry studies:

  • Characterization
  • Five Batch Analysis
  • Analytical Method Development and Validation
  • Persistence studies in Soil, Water and Air
  • Stability studies
  • Dose Formulation Analysis
  • Residue Analysis

Cosmetic – Alternative Assays

We conduct the following alternative assays to the cosmetic products

  • Transcutaneous Electrical Resistance Test in rats – Skin Corrosion
  • Skin Corrosion / Absorption test using Human Reconstructed skin
  • Hen’s Egg Test – Choroiallantoic Membrane – Eye Irritationx